Preliminary Scientific Program

Preliminary Scientific Program

Wednesday, 18 September
1:00 PM – 1:10 PM	Welcome and Introduction Alex Olivi, Michael McDermott
1:10 PM – 1:35 PM	Neurotraumatology and Neurosurgery: A Worldwide Approach Franco Servadei, Alberto Delitala, Roberto Delfini
1:40 PM – 2:00 PM	Trends & New Developments in Glioma Therapy Alberto Delitala, E. Antonio Chiocca, Roberto Delfini
2:05 PM – 2:25 PM	The Treatment of Pediatric AVMs Alberto Delitala, Roberto Delfini, Marco Cenzato
2:30 PM – 2:45 PM	Trends & New Developments in Endovascular Therapy Howard Riina, Roberto Delfini, Alberto Delitala
3:10 PM – 3:30 PM	Endonasal Approaches to Craniopharyngiomas Francesco Tomasello, Antonino Raco, Paolo Cappabianca
3:35 PM – 3:55 PM	Trends & New Developments in Spinal Surgery Mark Hadley, Antonino Raco, Francesco Tomasello
4:00 PM – 4:20 PM	Changing Paradigms in Neurosurgical Education. The Case of Virtual Reality and Surgical Simulation Antonino Raco, Francesco Tomasello, Francesco DiMeco
4:25 PM – 4:45 PM	Trends & New Developments in Functional - Epilepsy Francesco Tomasello, G. Rees Cosgrove, Antonino Raco
4:50 PM – 5:10 PM	Intraoperative Neurophysiological Monitoring in Spinal Cord Tumor Surgery: How Much Evidence Do We Need? Antonino Raco, Francesco Sala, Francesco Tomasello
7:30 PM – 12:00 AM	Evening Social Event: Opening Reception

Thursday, 19 September
7:30 AM – 7:35 AM	Welcoming Remarks Michael McDermott, Alex Olivi
7:35 AM – 8:45 AM	Peer Reviewed Abstract Session I: Functional Science Robert Gross, Daniel Yoshor Safety/Efficacy of Bone Marrow-Derived Mesenchymal Stem Cell (SB623) Implantation After Chronic Traumatic Brain Injury Gary Steinberg 7:35 AM – 7:45 AM Extracellular microRNAs in Blood Differentiate Between Ischemic and Hemorrhagic Stroke Yashar Kalani 7:45 AM – 7:55 AM Hemodynamic Predictors of Long-Term Patency in Cerebral Revascularization Surgery Fady Charbel 7:55 AM – 8:05 AM Early Results of Clinical Testing of a Visual Cortical Prosthetic in Blind Subjects Daniel Yoshor 8:05 AM – 8:15 AM Nerve transfers to improve upper extremity function and quality of life in tetraplegic patients Zack Ray 8:15 AM – 8:25 AM Mapping brain response patterns to Deep Brain Stimulation with fMRI Andres Lozano 8:25 AM – 8:35 AM Trigeminal Nerve Stimulation as a Neuroprotectant Raj Narayan 8:35 AM – 8:45 AM
8:45 AM – 9:25 AM	Peer Reviewed Abstract Session II: Spine Science Mark Shaffrey, Nicholas Theodore 12-Month Safety and Efficacy Results from the SCiStar Study – A Phase 1/2a Trial of Richard Fessler 8:45 AM – 8:55 AM Early Surgery and Recovery in Central Cord Syndrome: Analysis of 211 Patients from a Prospective, Multi-Center Dataset Michael Fehlings 8:55 AM – 9:05 AM Transpedicular vertebrectomy for thoracic spine metastasis Ehud Mendel 9:05 AM – 9:15 AM
9:35 AM – 10:45 AM	Peer Reviewed Abstract Session III: Tumor Science Mitchel Berger, E. Antonio Chiocca Meningioma Genomic Subgroup and Predicting Post-operative Patient Outcomes: Implications for Treatment and Follow-up Jennifer Moliterno 9:35 AM – 9:45 AM Oncolytic G207 Produces immunologic Signature Predicting Response to Therapy James Markert 9:45 AM – 9:55 AM Evolution of Low Grade Gliomas During Malignant Transformation Mitchel Berger 9:55 AM – 10:05 AM Outcomes from Asleep and Awake Dominant Temporal Lobe Glioma Surgery: Risk, Extent of Resection, and Survival Michael McDermott 10:05 AM – 10:15 AM Neurosurgical management of sinonasal malignancies involving the skullbase. A 25-year experience. Franco DeMonte 10:15 AM – 10:25 AM Opening of blood brain barrier in the hippocampus and entorhinal cortex in Alzheimer’s disease with focused ultrasound Ali Rezai 10:25 AM – 10:35 AM CAR T cell therapy for glioblastoma: Current observations and future directions Donald O'Rourke 10:35 AM – 10:45 AM
10:50 AM – 11:50 AM	Peer Reviewed Abstract Session IV: Vascular Science Robert Spetzler, Elad Levy Functional Connectivity Deficits After Subarachnoid Hemorrhage Gregory Zipfel 10:50 AM – 11:00 AM Microbiome Signatures of Cavernous Angioma Sean Polster 11:00 AM – 11:10 AM The New Generation Hydrogel Endovascular Aneurysm Treatment Trial (HEAT): Final Results Bernard Bendok 11:10 AM – 11:20 AM The R2eD AVM score: a novel predictive tool for arteriovenous malformation presentation with hemorrhage Judy Huang 11:20 AM – 11:30 AM Cerebral Aneurysm Formation and Rupture: Role of Nrf2 Signaling Aaron Dumont 11:30 AM – 11:40 AM Early Gene Deletion Generates a High-Fidelity Transgenic Mouse Model of Familial Brain Arteriovenous Malformations Michael Lawton 11:40 AM – 11:50 AM
12:00 PM – 12:50 PM	Special Lecture I Alexandra Golby, James Rutka The Rhetoric of Medicine: Lessons on Professionalism From Ancient Greece Nigel NicholsonNathan Selden 12:00 PM – 12:50 PM
5:30 PM – 10:00 PM	Evening Social Event: Visit to the Musei Vaticani and Sistine Chapel Dinner at the Paolo VI Residence and Terrace

Friday, 20 September
7:30 AM – 7:35 AM	Welcome & Remarks Alex Olivi, Michael McDermott
7:35 AM – 8:35 AM	Peer Reviewed Abstract Session V: Vascular Michael Lawton, E. Sander Connolly Deletions in CWH43 Cause Sporadic Idiopathic Normal Pressure Hydrocephalus Mark Johnson 7:35 AM – 7:45 AM NEWTON-2: Randomized, Double-blind, Placebo-controlled study of EG 1962 in Aneurysmal Subarachnoid Hemorrhage R. Loch Macdonald 7:45 AM – 7:55 AM When Flow Diversion Fails: Predictive Factors of Incomplete Aneurysm Occlusion after Pipeline Embolization Christopher Ogilvy 7:55 AM – 8:05 AM Transradial Cerebral Angiography: A Safer Alternative Felipe Albuquerque 8:05 AM – 8:15 AM Somatic mutations in cerebral aneurysms Rose Du 8:15 AM – 8:25 AM Intracranial Aneurysms: Does Size Really Matter? Philip Stieg 8:25 AM – 8:35 AM
8:35 AM – 9:15 AM	Peer Reviewed Abstract Session VI: Tumor Henry Brem, Donald O'Rourke Long-Term Outcomes in the Treatment of Pediatric Skull Base Chordomas Paul Gardner 8:35 AM – 8:40 AM MRI Perfusion Radiomic Machine Learning Identifies Pseudoprogression in Glioblastoma – A Multicenter Study Pascal Zinn 8:40 AM – 8:50 AM The evolution of epilepsy surgery for children: lessons from tuberous sclerosis complex over 20 years Howard Weiner 8:50 AM – 9:00 AM Stimulated Raman Histology for Rapid Neurosurgical Intraoperative Histology: A Prospective Series Allan Levi 9:00 AM – 9:10 AM Discussion Jean Regis 9:10 AM – 9:15 AM
9:30 AM – 10:30 AM	Peer Reviewed Abstract Session VII: Spine Kevin Foley, Praveen Mummaneni Early Results from the CSM-S RCT: Quality of Life, Cost, and Complications Zoher Ghogawala 9:30 AM – 9:40 AM Fusion for Spondylolisthesis Is Associated with Greater Improvements: A Multicenter Registry Study Kevin Foley 9:40 AM – 9:50 AM Frailty, Long-Term Outcomes and Management Implications for Type II Odontoid Fractures in the Elderly Michelle Clarke 9:50 AM – 10:00 AM The use of intraoperative sodium fluorescein for diagnostic biopsy of intramedullary spine cord lesions Timothy Ung 10:00 AM – 10:10 AM Robot-Assisted vs Freehand Instrumentation in Short-Segment Lumbar Fusion:Exp with Real-Time,Image-Guided Spinal Robot Nicholas Theodore 10:10 AM – 10:20 AM Maximal Safe Resection in Thalamic Gliomas is Superior to Biopsy: Personal Reflections on 40 Cases Mustafa Baskaya 10:20 AM – 10:30 AM
10:30 AM – 11:40 PM	Peer Reviewed Abstract Session VIII: Functional/Trauma/Vascular Bernard Bendok, Sepideh Amin-Hanjani Dopamine, serotonin, and norepinephrine micro-fluctuations during conscious choice and subjective experience in humans Charles Branch 10:30 AM – 10:40 AM Intracranially delivered IL-12 secreting CAR T cells recruit host immunity to eradicate heterogeneous GBM John Sampson 10:40 AM – 10:50 AM A New Treatment for Acute TBI – a phase II multicenter trial using novel MRI derivatives as surrogate outcome measures Howard Eisenberg 10:50 AM – 11:00 AM Dynamic blood brain barrier regulation in mild traumatic brain injury Gerald Grant 11:00 AM – 11:10 AM Computer-Learning to Identify High Risk Unruptured Aneurysms and Guide Decision Making: Rupture Resemblance Score Elad Levy 11:10 AM – 11:20 AM Distribution and radiologic features of SEDAVFs in a modern single-center series of patients with spinal vascular shunts Giuseppe Lanzino 11:20 AM – 11:30 AM HDFT as a tool to enhance outcomes in the management of hypereloquent lesions Robert Friedlander 11:30 AM – 11:40 AM
11:50 AM – 12:20 PM	Special Lecture II Luca di Montezemolo, Alex Olivi
12:20 PM – 1:20 PM	Presidential Address Introduction of the Academy President : Mark Johnson Mark Johnson 12:20 PM – 12:30 PM American Academy of Neurological Surgery Presidential Address: Quo Vadis, Academia? E. Antonio Chiocca 12:30 PM – 1:20 PM
5:30 PM – 10:00 PM	Evening Social Event: Academy Gala Dinner

Saturday, 21 September
7:30 AM – 8:25 AM	Special Lecture III: The Oldfield Lectureship E. Antonio Chiocca Introduction E. Antonio Chiocca 7:30 AM – 7:35 AM Oldfield Lecture: Bench to bedside development of a novel STAT3 inhibitor for CNS malignancies Amy Heimberger 7:35 AM – 8:05 AM NIH Funding Overview Stephen Korn 8:05 AM – 8:15 AM NREF Funding Overview Regis Haid 8:15 AM – 8:20 AM AAcNS/NREF Young Clinician Award Update Brian Gill 8:20 AM – 8:25 AM
8:25 AM – 8:30 AM	AAcNS/NREF Research Fellowship Grant Update Ben Grannan
8:30 AM – 8:40 AM	American Academy Young Clinician Investigator Award – North America: Single-cellular representations of semantic meaning during natural language perception Ben Grannan
8:40 AM – 8:50 AM	American Academy Young Clinician Investigator Award – Italy: Monitoring language networks in the asleep patient during surgery: an electrophysiological Davide Giampiccolo
8:55 AM – 9:30 AM	Special Lecture IV: Introduction of Academy Special Lecturer Alex Olivi 8:55 AM – 9:00 AM TBA Lecture Lamberto FrescobaldiAzienda Agricola Firenze 9:00 AM – 9:30 AM
9:30 AM – 10:30 AM	Peer Reviewed Abstract Session IX: Various topics Robert Harbaugh, Jacques Morcos Brain growth and developmental outcome after treatment of post-infectious hydrocephalus in infants in Uganda Abhaya Kulkarni 9:30 AM – 9:40 AM Impact on Facial Nerve Outcomes and Extent of Resection Using Subperineural Dissection Technique for Surgical Resection James Liu 9:40 AM – 9:50 AM Phase 0/1 Clinical Trial of Low-Dose Capecitabine in Recurrent GBM: Global Immune Fingerprinting of Tissue and Blood Michael Vogelbaum 9:50 AM – 10:00 AM Evolution of Low Grade Gliomas During Malignant Transformation Mitchel Berger 10:00 AM – 10:10 AM Cerebro-vascular remodeling following ischemic stroke: cellular and molecular mechanisms Robert Dempsey 10:10 AM – 10:20 AM Glioblastoma organoids: A model system for patient-specific therapeutic testing Steven Brem 10:20 AM – 10:30 AM
10:45 AM – 12:05 PM	Peer Reviewed Abstract Session X: Various topics Aviva Abosch, Michael McDermott Flies, worms and fish: What do these have to do with brain tumours? James Rutka 10:45 AM – 10:55 AM Real-time CED of Nanoliposomal CPT-11 for recurrent GBM: Interim results of a phase I clinical trial Manish Aghi 10:55 AM – 11:05 AM Leptomeningeal dissemination, a sinister pattern of medulloblastoma growth Daniel Fults 11:05 AM – 11:15 AM Characteristics of Clots Retrieved by Mechanical Thrombectomy Associated with Stroke Etiology and Device Performance Adnan Siddiqui 11:15 AM – 11:25 AM Integration of 5-ALA and CEUS in the Surgical Resection of High Grade Glioma Alex Olivi 11:25 AM – 11:35 AM Mesenchymal Stem Cell Delivery of Oncolytic Adenovirus Delta-24-RGD Following Surgical Resection of Glioblastoma Frederick Lang 11:35 AM – 11:45 AM An Epigenetic Liquid Biopsy Machine Learning Algorithm to Predict Glioma and Glioma Subtypes Steven Kalkanis 11:45 AM – 11:55 AM Recurrence Patterns in Skull Base Meningiomas and Role of Simpson Grading: Quo Vadis Anil Nanda 11:55 AM – 12:05 PM
12:10 PM – 12:15 PM	Closing Remarks & Meeting Adjourn Aviva Abosch

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81st Annual Meeting
Rome Cavakieri Waldorf Astoria | September 18-21, 2019

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Wednesday, 18 September

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