Preliminary Scientific Program

Preliminary Scientific Program

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Date

Wednesday

September 18, 2019

1:00-1:10 pm

Welcome and Introduction

PARTICIPANTS

Dr. Michael William McDermott

Alex Olivi

1:10-1:35 pm

Neurotraumatology and Neurosurgery: A Worldwide Approach

Spoken

PARTICIPANTS

Dr. Roberto Delfini

Dr. Alberto Delitala

Franco Servadei

1:40-2:00 pm

Trends & New Developments in Glioma Therapy

Spoken

PARTICIPANTS

Dr. E. Antonio Chiocca

Dr. Roberto Delfini

Dr. Alberto Delitala

2:05-2:25 pm

The Treatment of Pediatric AVMs

Spoken

PARTICIPANTS

Dr. Roberto Delfini

Dr. Alberto Delitala

Marco Cenzato

2:30-2:45 pm

Trends & New Developments in Endovascular Therapy

Spoken

PARTICIPANTS

Dr. Roberto Delfini

Dr. Alberto Delitala

Dr. Howard A. Riina

3:10-3:30 pm

Endonasal Approaches to Craniopharyngiomas

PARTICIPANTS

Antonino Raco

Dr. Francesco F. Tomasello

Dr. Paolo Cappabianca

3:35-3:55 pm

Trends & New Developments in Spinal Surgery

PARTICIPANTS

Dr. Mark N. Hadley

Antonino Raco

Dr. Francesco F. Tomasello

4:00-4:20 pm

Changing Paradigms in Neurosurgical Education. The Case of Virtual Reality and Surgical Simulation

PARTICIPANTS

Antonino Raco

Dr. Francesco DiMeco

Dr. Francesco F. Tomasello

4:25-4:45 pm

Trends & New Developments in Functional - Epilepsy

PARTICIPANTS

Dr. G. Rees "Rees" Cosgrove

Antonino Raco

Dr. Francesco F. Tomasello

4:50-5:10 pm

Intraoperative Neurophysiological Monitoring in Spinal Cord Tumor Surgery: How Much Evidence Do We Need?

PARTICIPANTS

Antonino Raco

Dr. Francesco F. Tomasello

Dr. Francesco Sala

7:30 pm-12:00 am

Evening Social Event: Opening Reception

Thursday

September 19, 2019

7:30-7:35 am

Welcoming Remarks

PARTICIPANTS

Dr. Michael William McDermott

Alex Olivi

7:35-8:45 am

Peer Reviewed Abstract Session I: Functional Science

PRESENTATIONS

Time	Title	Participant
7:35-7:45 am	Safety/Efficacy of Bone Marrow-Derived Mesenchymal Stem Cell (SB623) Implantation After Chronic Traumatic Brain Injury	Dr. Gary K. Steinberg
7:45-7:55 am	Extracellular microRNAs in Blood Differentiate Between Ischemic and Hemorrhagic Stroke	Yashar Kalani
7:55-8:05 am	Hemodynamic Predictors of Long-Term Patency in Cerebral Revascularization Surgery	Dr. Fady T. Charbel
8:05-8:15 am	Early Results of Clinical Testing of a Visual Cortical Prosthetic in Blind Subjects	Dr. Daniel Yoshor
8:15-8:25 am	Nerve transfers to improve upper extremity function and quality of life in tetraplegic patients	Dr. Wilson Zachary Ray
8:25-8:35 am	Mapping brain response patterns to Deep Brain Stimulation with fMRI	Dr. Andres M. Lozano
8:35-8:45 am	Trigeminal Nerve Stimulation as a Neuroprotectant	Dr. Raj K. Narayan

PARTICIPANTS

Dr. Daniel Yoshor

Dr. Robert E. Gross

8:45-9:25 am

Peer Reviewed Abstract Session II: Spine Science

PRESENTATIONS

Time	Title	Participant
8:45-8:55 am	12-Month Safety and Efficacy Results from the SCiStar Study – A Phase 1/2a Trial of	Richard David Fessler
8:55-9:05 am	Early Surgery and Recovery in Central Cord Syndrome: Analysis of 211 Patients from a Prospective, Multi-Center Dataset	Dr. Michael G. Fehlings
9:05-9:15 am	Transpedicular vertebrectomy for thoracic spine metastasis	Dr. Ehud Mendel

PARTICIPANTS

Dr. Nicholas Theodore

Dr. Mark Edwin Shaffrey

9:35-10:45 am

Peer Reviewed Abstract Session III: Tumor Science

PRESENTATIONS

Time	Title	Participant
9:35-9:45 am	Meningioma Genomic Subgroup and Predicting Post-operative Patient Outcomes: Implications for Treatment and Follow-up	Dr. Jennifer A. Moliterno
9:45-9:55 am	Oncolytic G207 Produces immunologic Signature Predicting Response to Therapy	Dr. James M. Markert, Jr.
9:55-10:05 am	Evolution of Low Grade Gliomas During Malignant Transformation	Dr. Mitchel S. Berger
10:05-10:15 am	Outcomes from Asleep and Awake Dominant Temporal Lobe Glioma Surgery: Risk, Extent of Resection, and Survival	Dr. Michael William McDermott
10:15-10:25 am	Neurosurgical management of sinonasal malignancies involving the skullbase. A 25-year experience.	Dr. Franco DeMonte
10:25-10:35 am	Opening of blood brain barrier in the hippocampus and entorhinal cortex in Alzheimer’s disease with focused ultrasound	Dr. Ali R. Rezai
10:35-10:45 am	CAR T cell therapy for glioblastoma: Current observations and future directions	Dr. Donald M. O'Rourke

PARTICIPANTS

Dr. E. Antonio Chiocca

Dr. Mitchel S. Berger

10:50-11:50 am

Peer Reviewed Abstract Session IV: Vascular Science

PRESENTATIONS

Time	Title	Participant
10:50-11:00 am	Functional Connectivity Deficits After Subarachnoid Hemorrhage	Dr. Gregory J. Zipfel
11:00-11:10 am	Microbiome Signatures of Cavernous Angioma	Dr. Sean P Polster
11:10-11:20 am	The New Generation Hydrogel Endovascular Aneurysm Treatment Trial (HEAT): Final Results	Dr. Bernard R. Bendok
11:20-11:30 am	The R2eD AVM score: a novel predictive tool for arteriovenous malformation presentation with hemorrhage	Dr. Judy Huang
11:30-11:40 am	Cerebral Aneurysm Formation and Rupture: Role of Nrf2 Signaling	Dr. Aaron S. Dumont
11:40-11:50 am	Early Gene Deletion Generates a High-Fidelity Transgenic Mouse Model of Familial Brain Arteriovenous Malformations	Dr. Michael T. Lawton

PARTICIPANTS

Dr. Robert F. Spetzler

Dr. Elad I. Levy

12:00-12:50 pm

Special Lecture I

PRESENTATIONS

Time	Title	Participant	Number
12:00 pm-12:50 pm	The Rhetoric of Medicine: Lessons on Professionalism From Ancient Greece	Dr. Nathan R. Selden Nigel Nicholson

PARTICIPANTS

Dr. Alexandra J. Golby

Dr. James T. Rutka

5:30-10:00 pm

Evening Social Event: Visit to the Musei Vaticani and Sistine Chapel Dinner at the Paolo VI Residence and Terrace

Friday

September 20, 2019

7:30-7:35 am

Welcome & Remarks

PARTICIPANTS

Dr. Michael William McDermott

Alex Olivi

7:35-8:35 am

Peer Reviewed Abstract Session V: Vascular

PRESENTATIONS

Time	Title	Participant
7:35-7:45 am	Deletions in CWH43 Cause Sporadic Idiopathic Normal Pressure Hydrocephalus	Dr. Mark D. Johnson
7:45-7:55 am	NEWTON-2: Randomized, Double-blind, Placebo-controlled study of EG 1962 in Aneurysmal Subarachnoid Hemorrhage	Dr. R. Loch Macdonald
7:55-8:05 am	When Flow Diversion Fails: Predictive Factors of Incomplete Aneurysm Occlusion after Pipeline Embolization	Dr. Christopher S. Ogilvy
8:05-8:15 am	Transradial Cerebral Angiography: A Safer Alternative	Dr. Felipe Albuquerque
8:15-8:25 am	Somatic mutations in cerebral aneurysms	Dr. Rose Du
8:25-8:35 am	Intracranial Aneurysms: Does Size Really Matter?	Dr. Philip E. Stieg

PARTICIPANTS

Dr. E. Sander Connolly, Jr.

Dr. Michael T. Lawton

8:35-9:15 am

Peer Reviewed Abstract Session VI: Tumor

PRESENTATIONS

Time	Title	Participant
8:35-8:40 am	Long-Term Outcomes in the Treatment of Pediatric Skull Base Chordomas	Dr. Paul A. Gardner
8:40-8:50 am	MRI Perfusion Radiomic Machine Learning Identifies Pseudoprogression in Glioblastoma – A Multicenter Study	Dr. Pascal O. Zinn
8:50-9:00 am	The evolution of epilepsy surgery for children: lessons from tuberous sclerosis complex over 20 years	Dr. Howard L. Weiner
9:00-9:10 am	Stimulated Raman Histology for Rapid Neurosurgical Intraoperative Histology: A Prospective Series	Dr. Allan D. Levi
9:10-9:15 am	Discussion	Jean Regis

PARTICIPANTS

Dr. Henry Brem

Dr. Donald M. O'Rourke

9:30-10:30 am

Peer Reviewed Abstract Session VII: Spine

PRESENTATIONS

Time	Title	Participant
9:30-9:40 am	Early Results from the CSM-S RCT: Quality of Life, Cost, and Complications	Dr. Zoher Ghogawala
9:40-9:50 am	Fusion for Spondylolisthesis Is Associated with Greater Improvements: A Multicenter Registry Study	Dr. Kevin T. Foley
9:50-10:00 am	Frailty, Long-Term Outcomes and Management Implications for Type II Odontoid Fractures in the Elderly	Dr. Michelle J. Clarke
10:00-10:10 am	The use of intraoperative sodium fluorescein for diagnostic biopsy of intramedullary spine cord lesions	Dr. Timothy H Ung
10:10-10:20 am	Robot-Assisted vs Freehand Instrumentation in Short-Segment Lumbar Fusion:Exp with Real-Time,Image-Guided Spinal Robot	Dr. Nicholas Theodore
10:20-10:30 am	Maximal Safe Resection in Thalamic Gliomas is Superior to Biopsy: Personal Reflections on 40 Cases	Dr. Mustafa Kemal Baskaya

PARTICIPANTS

Dr. Kevin T. Foley

Dr. Praveen V. Mummaneni

10:30 am-11:40 pm

Peer Reviewed Abstract Session VIII: Functional/Trauma/Vascular

Spoken

PRESENTATIONS

Time	Title	Participant
10:30-10:40 am	Dopamine, serotonin, and norepinephrine micro-fluctuations during conscious choice and subjective experience in humans	Dr. Charles L. Branch, Jr.
10:40-10:50 am	Intracranially delivered IL-12 secreting CAR T cells recruit host immunity to eradicate heterogeneous GBM	Dr. John H. Sampson
10:50-11:00 am	A New Treatment for Acute TBI – a phase II multicenter trial using novel MRI derivatives as surrogate outcome measures	Dr. Howard M. Eisenberg
11:00-11:10 am	Dynamic blood brain barrier regulation in mild traumatic brain injury	Dr. Gerald A. Grant
11:10-11:20 am	Computer-Learning to Identify High Risk Unruptured Aneurysms and Guide Decision Making: Rupture Resemblance Score	Dr. Elad I. Levy
11:20-11:30 am	Distribution and radiologic features of SEDAVFs in a modern single-center series of patients with spinal vascular shunts	Dr. Giuseppe Lanzino
11:30-11:40 am	HDFT as a tool to enhance outcomes in the management of hypereloquent lesions	Dr. Robert Max Friedlander

PARTICIPANTS

Dr. Bernard R. Bendok

Dr. Sepideh Amin-Hanjani

11:50 am-12:20 pm

Special Lecture II

PARTICIPANTS

Luca di Montezemolo

Alex Olivi

12:20-1:20 pm

Presidential Address

PRESENTATIONS

Time	Title	Participant	Number
12:20 pm-12:30 pm	Introduction of the Academy President : Mark Johnson	Dr. Mark D. Johnson
12:30 pm-1:20 pm	American Academy of Neurological Surgery Presidential Address: Quo Vadis, Academia?	Dr. E. Antonio Chiocca

5:30-10:00 pm

Evening Social Event: Academy Gala Dinner

Saturday

September 21, 2019

7:30-8:25 am

Special Lecture III: The Oldfield Lectureship

PRESENTATIONS

Time	Title	Participant
7:30-7:35 am	Introduction	Dr. E. Antonio Chiocca
7:35-8:05 am	Oldfield Lecture: Bench to bedside development of a novel STAT3 inhibitor for CNS malignancies	Dr. Amy B. Heimberger
8:05-8:15 am	NIH Funding Overview	Dr. Stephen J. Korn
8:15-8:20 am	NREF Funding Overview	Dr. Regis W. Haid, Jr.
8:20-8:25 am	AAcNS/NREF Young Clinician Award Update	Brian John Andrew Gill

PARTICIPANTS

Dr. E. Antonio Chiocca

8:25-8:30 am

AAcNS/NREF Research Fellowship Grant Update

PARTICIPANTS

Dr. Ben L Grannan

8:30-8:40 am

American Academy Young Clinician Investigator Award – North America: Single-cellular representations of semantic meaning during natural language perception

PARTICIPANTS

Dr. Ben L Grannan

8:40-8:50 am

American Academy Young Clinician Investigator Award – Italy: Monitoring language networks in the asleep patient during surgery: an electrophysiological

PARTICIPANTS

Davide Giampiccolo

8:55-9:30 am

Special Lecture IV:

PRESENTATIONS

Time	Title	Participant	Number
8:55-9:00 am	Introduction of Academy Special Lecturer	Alex Olivi
9:00-9:30 am	TBA Lecture	Azienda Agricola "Marchesi Frescobaldi" Firenze Lamberto Frescobaldi

9:30-10:30 am

Peer Reviewed Abstract Session IX: Various topics

PRESENTATIONS

Time	Title	Participant
9:30-9:40 am	Brain growth and developmental outcome after treatment of post-infectious hydrocephalus in infants in Uganda	Dr. Abhaya Vivek Kulkarni
9:40-9:50 am	Impact on Facial Nerve Outcomes and Extent of Resection Using Subperineural Dissection Technique for Surgical Resection	Dr. James K. Liu
9:50-10:00 am	Phase 0/1 Clinical Trial of Low-Dose Capecitabine in Recurrent GBM: Global Immune Fingerprinting of Tissue and Blood	Dr. Michael A. Vogelbaum
10:00-10:10 am	Evolution of Low Grade Gliomas During Malignant Transformation	Dr. Mitchel S. Berger
10:10-10:20 am	Cerebro-vascular remodeling following ischemic stroke: cellular and molecular mechanisms	Dr. Robert J. Dempsey
10:20-10:30 am	Glioblastoma organoids: A model system for patient-specific therapeutic testing	Dr. Steven Brem

PARTICIPANTS

Dr. Jacques J. Morcos

Dr. Robert E. Harbaugh

10:45 am-12:05 pm

Peer Reviewed Abstract Session X: Various topics

PRESENTATIONS

Time	Title	Participant
10:45-10:55 am	Flies, worms and fish: What do these have to do with brain tumours?	Dr. James T. Rutka
10:55-11:05 am	Real-time CED of Nanoliposomal CPT-11 for recurrent GBM: Interim results of a phase I clinical trial	Dr. Manish Kumar Aghi
11:05-11:15 am	Leptomeningeal dissemination, a sinister pattern of medulloblastoma growth	Dr. Daniel W. Fults, III
11:15-11:25 am	Characteristics of Clots Retrieved by Mechanical Thrombectomy Associated with Stroke Etiology and Device Performance	Dr. Adnan Hussain Siddiqui
11:25-11:35 am	Integration of 5-ALA and CEUS in the Surgical Resection of High Grade Glioma	Alex Olivi
11:35-11:45 am	Mesenchymal Stem Cell Delivery of Oncolytic Adenovirus Delta-24-RGD Following Surgical Resection of Glioblastoma	Dr. Frederick F. Lang
11:45-11:55 am	An Epigenetic Liquid Biopsy Machine Learning Algorithm to Predict Glioma and Glioma Subtypes	Dr. Steven N. Kalkanis
11:55 am-12:05 pm	Recurrence Patterns in Skull Base Meningiomas and Role of Simpson Grading: Quo Vadis	Dr. Anil Nanda

PARTICIPANTS

Dr. Aviva Abosch

Dr. Michael William McDermott

12:10-12:15 pm

Closing Remarks & Meeting Adjourn

PARTICIPANTS

Dr. Aviva Abosch

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81st Annual Meeting
Rome Cavakieri Waldorf Astoria | September 18-21, 2019

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Wednesday

September 18, 2019

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Thursday

September 19, 2019

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Friday

September 20, 2019

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Saturday

September 21, 2019

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