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    Wednesday, September 18, 2019

    1:00 – 1:10 Welcome and Introduction
    Alex Olivi (Local Arrangements Chair) & Michael McDermott (Scientific Program Chair)  
    1:10 – 1:35 Neurotraumatology and Neurosurgery: A Worldwide Approach
    Franco Servadei (Italy)  
    1:40 – 2:00 Trends & New Developments in Glioma Therapy
    E. Antonio “Nino” Chiocca (AAcNS)  
    2:05 – 2:25 The Treatment of Pediatric AVMs
    Marco Cenzato (Italy)  
    2:30 – 2:45 Trends & New Developments in Endovascular Therapy
    Howard Riina (AAcNS)  
      2:45 – 3:05  BREAK
    3:10 – 3:30 Endonasal Approaches to Craniopharyngiomas
    Paolo Cappabianca (Italy)  
    3:35 – 3:55 Trends & New Developments in Spinal Surgery
    Mark Hadley (AAcNS)  
    4:00 – 4:20 Changing Paradigms in Neurosurgical Education. The Case of Virtual Reality and Surgical Simulation
    Francesco DiMeco (Italy)  
    4:25 – 4:45 Trends & New Developments in Functional - Epilepsy
    G. Rees Cosgrove (AAcNS)  
    4:50 – 5:10 Intraoperative Neurophysiological Monitoring in Spinal Cord Tumor Surgery: How Much Evidence Do We Need?
    Francesco Sala (Italy)  
      5:30 - Adjourn
    7:30 pm Evening Social Event: Opening Reception, Terraza Aranci, Waldorf Astoria Cavalieri Hotel, Business Casual Attire recommended

    Thursday, September 19, 2019

    7:30 – 7:35 WELCOMING REMARKS
    Michael McDermott (Scientific Program Chair) & Alex Olivi (Local Arrangements Chair)  
    7:35 – 8:45 Peer Reviewed Abstract Session I: Functional Science
    Moderators: Robert Gross & Daniel Yoshor
    7:35 – 7:45 Safety/Efficacy of Bone Marrow-Derived Mesenchymal Stem Cell (SB623) Implantation After Chronic Traumatic Brain Injury
    Gary Steinberg  
    7:45 – 7:55 Deletions in CWH43 Cause Sporadic Idiopathic Normal Pressure Hydrocephalus
    Mark Johnson  
    7:55 – 8:05 Hemodynamic Predictors of Long-Term Patency in Cerebral Revascularization Surgery
    Fady Charbel  
    8:05 – 8:15 Early Results of Clinical Testing of a Visual Cortical Prosthetic in Blind Subjects
    Daniel Yoshor  
    8:15 – 8:25 Nerve transfers to improve upper extremity function and quality of life in tetraplegic patients
    Wilson Ray  
    8:25 – 8:35 Mapping brain response patterns to Deep Brain Stimulation with fMRI
    Andres Lozano  
    8:35 – 8:45 Trigeminal Nerve Stimulation as a Neuroprotectant
    Raj Narayan  
    8:45-9:25 Peer Reviewed Abstract Session II: Spine Science Moderators:
    Nicholas Theodore & Mark Shaffrey
    8:45 - 8:55 12-Month Safety and Efficacy Results from the SCiStar Study – A Phase 1/2a Trial of
    Richard Fessler  
    8:55 - 9:05 Early Surgery and Recovery in Central Cord Syndrome: Analysis of 211 Patients from a Prospective, Multi-Center Dataset
    Michael Fehlings  
    9:05 - 9:15 Transpedicular vertebrectomy for thoracic spine metastasis
    Ehud Mendel  
    9:15 - 9:25 Sexual Dysfunction: Prevalence, Prognosis, and Predictors of Outcomes in Patients Operated for Lumbar Spondylolisthesis
    Praveen Mummaneni  
      9:25 - 9:35 Break
    9:35 - 10:45 Peer Reviewed Abstract Session III: Tumor Science
    Moderators: Nino Chiocca Mitchel Berger  
    9:35 - 9:45 Meningioma Genomic Subgroup and Predicting Post-operative Patient Outcomes: Implications for Treatment and Follow-up
    Jennifer Moliterno  
    9:45 - 9:55 Oncolytic G207 Produces immunologic Signature Predicting Response to Therapy
    James Markert  
    9:55 - 10:05 Bench to bedside development of a novel STAT3 inhibitor for CNS malignancies
    Amy Heimberger  
    10:05 - 10:15 Outcomes from Asleep and Awake Dominant Temporal Lobe Glioma Surgery: Risk, Extent of Resection, and Survival
    Michael McDermott  
    10:15 - 10:25 Neurosurgical management of sinonasal malignancies involving the skullbase. A 25-year experience.
    Franco DeMonte  
    10:25 - 10:35 Intracranially delivered IL-12 secreting CAR T cells recruit host immunity to eradicate heterogeneous GBM
    John Sampson  
    10:35 - 10:45 CAR T cell therapy for glioblastoma: Current observations and future directions
    Don O’Rourke  
    10:50-11:50 Peer Reviewed Abstract Session 4: Vascular Science
    Moderators: Elad Levy & Robert Spetzler  
    10:50 - 11:00 Functional Connectivity Deficits After Subarachnoid Hemorrhage
    Greg Zipfel  
    11:00 - 11:10 Microbiome Signatures of Cavernous Angioma
    Issam Awad  
    11:10 - 11:20 The New Generation Hydrogel Endovascular Aneurysm Treatment Trial (HEAT): Final Results
    Bernard Bendok  
    11:20 - 11:30 The R2eD AVM score: a novel predictive tool for arteriovenous malformation presentation with hemorrhage
    Judy Huang  
    11:30-11:40 Cerebral Aneurysm Formation and Rupture: Role of Nrf2 Signaling
    Aaron Dumont  
    11:40 - 11:50 Early Gene Deletion Generates a High-Fidelity Transgenic Mouse Model of Familial Brain Arteriovenous Malformations
    Michael Lawton  
      11:50 - 12:00 Break
    12:00 - 12:50 Special Lecture I: The Rhetoric of Medicine: Lessons on Professionalism From Ancient Greece Nate Selden/Nigel Nicholson
    Moderator: Alex Golby / James Rutka
    Evening Social Event: Visit to the Musei Vaticani and Sistine Chapel Dinner at the Paolo VI Residence and Terrace Buses depart from hotel at 5:30 pm- Business casual attire recommended

    Friday, September 20, 2019

    7:30 – 7:35 WELCOME & REMARKS
    Michael McDermott (Scientific Program Chair) & Alex Olivi (Local Arrangements Chair)  
    7:35-8:35 Peer Reviewed Abstract Session V: Vascular
    Moderators: Michael Lawton & E. Sander Connolly  
    7:35-7:45 Extracellular microRNAs in Blood Differentiate Between Ischemic and Hemorrhagic Stroke
    Robert Spetzler  
    7:45-7:55 NEWTON-2: Randomized, Double-blind, Placebo-controlled study of EG 1962 in Aneurysmal Subarachnoid Hemorrhage
    Loch MacDonald  
    7:55-8:05 When Flow Diversion Fails: Predictive Factors of Incomplete Aneurysm Occlusion after Pipeline Embolization
    Chris Ogilvy  
    8:05-8:15 Transradial Cerebral Angiography: A Safer Alternative
    Felipe Albuquerque  
    8:15-8:25 Somatic mutations in cerebral aneurysms
    Rose Du  
    8:25-8:35 Intracranial Aneurysms: Does Size Really Matter?
    Phil Stieg  
    8:35-9:15 Peer Reviewed Abstract Session VI: Tumor
    Moderators: Henry Brem / Don O’Rourke
    8:35-8:40 Long-Term Outcomes in the Treatment of Pediatric Skull Base Chordomas
    Paul Gardner  
    8:40-8:50 MRI Perfusion Radiomic Machine Learning Identifies Pseudoprogression in Glioblastoma – A Multicenter Study
    Greg Fuller  
    8:50-9:00 The evolution of epilepsy surgery for children: lessons from tuberous sclerosis complex over 20 years
    Howard Weiner  
    9:00-9:10 Stimulated Raman Histology for Rapid Neurosurgical Intraoperative Histology: A Prospective Series
    Allan Levi  
    9:10-9:15 Discussion
      9:15-9:30 Break
    9:30-10:30 Peer Reviewed Abstract Session VII: Spine
    Moderators: Kevin Foley & Praveen Mummaneni
    9:30-9:40 Early Results from the CSM-S RCT: Quality of Life, Cost, and Complications
    Robert Heary  
    9:40-9:50 Fusion for Spondylolisthesis Is Associated with Greater Improvements: A Multicenter Registry Study
    Kevin Foley  
    9:50-10:00 Frailty, Long-Term Outcomes and Management Implications for Type II Odontoid Fractures in the Elderly
    Michelle Clarke  
    10:00-10:10 The use of intraoperative sodium fluorescein for diagnostic biopsy of intramedullary spine cord lesions
    Kevin Lillehei  
    10:10-10:20 Robot-Assisted vs Freehand Instrumentation in Short-Segment Lumbar Fusion: Experience with Real-Time, Image-Guided Spinal Robot
    Nicholas Theodore  
    10:20-10:30 Maximal Safe Resection in Thalamic Gliomas is Superior to Biopsy: Personal Reflections on 40 Cases
    Mustafa Baskaya  
    10:30-11:30 Peer Reviewed Abstract Session VIII: Functional/Trauma/Vascular
    Moderators: Bernard Bendok / Sepi Amin-Hanjani  
    10:30-10:40 Dopamine, serotonin, and norepinephrine micro-fluctuations during conscious choice and subjective experience in humans
    Charles Branch  
    10:40-10:50 Opening of blood brain barrier in the hippocampus and entorhinal cortex in Alzheimer’s disease with focused ultrasound
    Ali Rezai  
    10:50 - 11:00 A New Treatment for Acute TBI – a phase II multicenter trial using novel MRI derivatives as surrogate outcome measures
    Howard Eisenberg  
    11:00-11:10 Dynamic blood brain barrier regulation in mild traumatic brain injury
    Gerald Grant  
    11:10-11:20 Computer-Learning to Identify High Risk Unruptured Aneurysms and Guide Decision Making: Rupture Resemblance Score
    Elad Levy  
    11:20-11:30 Distribution and radiologic features of SEDAVFs in a modern single-center series of patients with spinal vascular shunts
    Giuseppe Lanzino  
    11:30 -11:40 HDFT as a tool to enhance outcomes in the management of hypereloquent lesions
    Robert Friedlander  
      11:40-11:50 Break
    11:50-12:20 Special Lecture 2
    Moderator: Alex Olivi
    Title: ??
    Luca di Montezemolo
    12:20 - 1:20 Presidential Address
    12:20 - 12:30 Introduction of the Academy President : Mark Johnson
    12:30 - 1:20 American Academy of Neurological Surgery Presidential Address Nino Chiocca, MD
      Evening Social Event:
    Academy Gala Dinner
    Villa Miani
    Attire: Black Tie Optional


    Saturday, September 21, 2019

    7:30 – 8:25 Special Lecture 3: The Oldfield Lectureship
    7:30 – 7:35 Introduction, Moderator: Nino Chiocca
    7:35 - 8:05 Oldfield Lecture: Bench to bedside development of a novel STAT3 inhibitor for CNS malignancies - Amy Heimberger
    8:05 - 8:15 NIH Funding Overview: Steve Korn
    8:15 - 8:20 NREF Funding Overview: Reg Haid
    8:20 - 8:25 AAcNS/NREF Young Clinician Award Update – Brian JA Gill
    8:25 - 8:30 AAcNS/NREF Research Fellowship Grant Update
    Benjamin Grannan  
    8:30 - 8:40 American Academy Young Clinician Investigator Award – North America Single-cellular representations of semantic meaning during natural language perception
    Benjamin L. Grannan  
    8:40 - 8:50 American Academy Young Clinician Investigator Award – Italy Monitoring language networks in the asleep patient during surgery: an electrophysiological approach
    Davide Giampiccolo  
    8:55 – 9:30 Special Lecture 4:
    8:55-9:00 Introduction of Academy Special Lecturer: Alex Olivi
    9:00-9:30 Speaker : Lamberto Frescobaldi, President
    Azienda Agricola “Marchesi Frescobaldi” Firenze
    9:30 - 10:30 Peer Reviewed Abstract Session 9: Various topics
    Moderators: Jacques Morcos / Robert Harbaugh
    9:30-9:40 Brain growth and developmental outcome after treatment of post-infectious hydrocephalus in infants in Uganda
    Steven Schiff  
    9:40-9:50 Impact on Facial Nerve Outcomes and Extent of Resection Using Subperineural Dissection Technique for Surgical Resection
    James Liu  
    9:50-10:00 Phase 0/1 Clinical Trial of Low-Dose Capecitabine in Recurrent GBM: Global Immune Fingerprinting of Tissue and Blood
    Michael Vogelbaum  
    10:00-10:10 Evolution of Low Grade Gliomas During Malignant Transformation.
    Mitchel S. Berger  
    10:10-10:20 Cerebro-vascular remodeling following ischemic stroke: cellular and molecular mechanisms.
    Robert Dempsey  
    10:20-10:30 Glioblastoma organoids: A model system for patient-specific therapeutic testing
    Steven Brem  
      10:30-10:45 Break
    10:45-11:55 Peer Reviewed Abstract Session 10: Various topics
    Moderators: Michael McDermott / Aviva Abosch  
    10:45-10:55 Flies, worms and fish: What do these have to do with brain tumours?
    Jim Rutka  
    10:55-11:05 Real-time CED of Nanoliposomal CPT-11 for recurrent GBM: Interim results of a phase I clinical trial
    Manish Aghi  
    11:05-11:15 Leptomeningeal dissemination, a sinister pattern of medulloblastoma growth
    Daniel Fults  
    11:15-11:25 Characteristics of Clots Retrieved by Mechanical Thrombectomy Associated with Stroke Etiology and Device Performance
    Adnan Siddiqui  
    11:25-11:35 Integration of 5-ALA and CEUS in the Surgical Resection of High Grade Glioma
    Alex Olivi  
    11:35-11:45 Mesenchymal Stem Cell Delivery of Oncolytic Adenovirus Delta-24-RGD Following Surgical Resection of Glioblastoma
    Fred Lang  
    11:45-11:55 An Epigenetic Liquid Biopsy Machine Learning Algorithm to Predict Glioma and Glioma Subtypes
    Steve Kalkanis  
    11:55-12:05 Recurrence Patterns in Skull Base Meningiomas and Role of Simpson Grading: Quo Vadis
    Anil Nanda  
    12:10 Closing Remarks Meeting Adjourn
    2020 Scientific Chair - Aviva Abosch  

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