Dr. Matthew Ewend is Chair of the Department of Neurosurgery at the University of North Carolina, and he is a member of the Departments of Medicine and Radiation Oncology. Dr. Ewend completed his medical school, neurosurgery residency and neuro-oncology fellowship at Johns Hopkins University. After completing his training in 1997, he moved to the University of North Carolina. In 2004, he became the Chief of the Division of Neurosurgery. When Neurosurgery became a Department of the School of Medicine in 2010, Dr Ewend was its founding Chair. Dr. Ewend is also the program leader for Neuro-oncology in the UNC Lineberger Comprehensive Cancer Center.
Dr. Ewend’s research interests lie in the area of novel therapeutics for treatment of metastatic and primary brain tumors. He has a particular interest in the use of local therapy for treatment of brain metastases and has published both preclinical and clinical work translating these laboratory findings into the patient setting. He has been the principle investigator for two multicenter studies utilizing local chemotherapy as a strategy for isolated brain metastases. Dr. Ewend has also been a key contributor to the UNC vascular imaging laboratory which has worked to use tumor vessel size and shape as a marker for tumor malignancy. This work has been performed in conjunction with Dr. Elizabeth Bullitt in the CASILAB.
Clinically, Dr. Ewend has strong interest in endoscopic skull base surgery and in surgical and radiosurgical treatment of brain metastases. Partnering with ENT surgeons, Dr. Ewend has performed over 350 endoscopic skull base surgeries for resections of meningiomas, craniopharyngiomas, pituitary adenomas, and other pathology of the anterior skull base. In addition, Dr. Ewend is the co-director of the UNC CyberKnife.
Under Dr. Ewend’s tenure as Division Chief and now Department Chair, the program has grown from three to ten full time neurosurgeons, six based in Chapel Hill and four at a new neurosurgery site in Pinehurst, North Carolina. Dr. Ewend is the Director of the Neuroscience Strategic Planning Program for the Health Care System and is a member of the Healthcare System’s IT Committee.
Dr. Ewend and his wife, Dr. Lisa Carey (who is the medical director of the UNC Breast Cancer Program) have 3 children. Dr. Ewend earned his private pilot certificate in the summer of 2009.