• Authors: Daniel K. Resnick, M.D.; Paul A. Anderson, M.D.; Michael G. Kaiser, M.D.; Michael W. Groff, M.D.; Robert F. Heary, M.D.; Langston T. Holly, M.D.; Praveen V. Mummaneni, M.D.; Timothy C. Ryken, M.D.; Tanvir F. Choudhri, M.D.; Edward J. Vresilovic, M.D., Ph.D; Paul G. Matz, M.D.

    abstract download pdf


    The objective of this systematic review was to use evidence-based medicine to examine the diagnostic and therapeutic utility of intraoperative electrophysiological (EP) monitoring in the surgical treatment of cervical degenerative disease.


    The National Library of Medicine and Cochrane Database were queried using MeSH headings and key words relevant to cervical spine surgery and EP monitoring. The guidelines group assembled an evidentiary table summarizing the quality of evidence (Classes I–III). The group formulated recommendations that contained the degree of strength based on the Scottish Intercollegiate Guidelines network. Validation was done through peer review by the Joint Guidelines Committee of the American Association of Neurological Surgeons/Congress of Neurological Surgeons.


    The reliance on changes in EP monitoring as an indication to alter a surgical plan or administer steroids has not been observed to reduce the incidence of neurological injury during routine surgery for cervical spondylotic myelopathy or cervical radiculopathy (Class III). However, there is an absence of study data examining the benefit of altering a surgical plan due to EP changes.


    Although the use of EP monitoring may serve as a sensitive means to diagnose potential neurological injury during anterior spinal surgery for cervical spondylotic myelopathy, the practitioner must understand that intraoperative EP worsening is not specific—it may not represent clinical worsening and its recognition does not necessarily prevent neurological injury, nor does it result in improved outcome (Class II). Intraoperative improvement in EP parameters/indices does not appear to forecast outcome with reliability (conflicting Class I data).

    Abbreviations used in this paper: CSM = cervical spondylotic myelopathy; EMG = electromyography; EP = electrophysiological; MEP = motor evoked potential; SSEP = somatosensory evoked potential; TcMEP = transcranial MEP.

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